Preheat oven to 400 degrees. Coat the bottom and sides of a 13x9x2 baking pan with nonstick spray. Pulse bacon in a food processor until coarsely ground. Transfer to a large bowl. Add ground chuck and next 13 ingredients. Mix well to evenly incorporate. Transfer meatloaf mixture to pan and form into a long log (about 12x5). Smooth loaf all over..

Bake meatloaf until an instant-read thermometer inserted into the center registers 150 degrees, about 35 minutes.

Stir ketchup and pureed chipotle chile in a small bowl. Spread 1/2 cup chipotle barbecue sauce all over the top and sides of meatloaf. Bake meatloaf until instant-read thermometer inserted into the center registers 165 degrees, about 10 minutes longer. Serve with remaining chipotle barbecue sauce alongside.